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For adults initiating Ozempic, a practical follow-up timeline includes: a check-in at 4 weeks (end of 0.25 mg phase) to assess GI tolerability, a lab draw at 12 weeks (typically at 0.5 mg or early 1 mg phase) to measure A1C and fasting glucose, and a comprehensive visit at 24 weeks to determine if the current dose is sufficient or if escalation to 2 mg is warranted

No trial has established one step-down schedule

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A lyophilized peptide is relatively resilient, but it's not invincible

Freezing causes irreversible damage to the protein structure of GLP-1 medications